Njira imodzi yomwe maselo a khansa amabisala ku chitetezo cha mthupi ndi kupanga chotchinga chochepa kwambiri chotchedwa glycocalyx. Mu kafukufuku watsopanoyu, ofufuzawo adawunika zomwe zili pachiwopsezochi ndi kusamvana komwe kunalipo kale, akuwulula zambiri zomwe zingathandize kukonza ma immunotherapies amakono a khansa yama cell.
Maselo a khansa nthawi zambiri amapanga glycocalyx yokhala ndi ma cell a cell mucins, omwe amaganiziridwa kuti amathandiza kuteteza maselo a khansa kuti asawukidwe ndi maselo oteteza thupi. Komabe, kumvetsetsa kwakuthupi kwa chotchinga ichi kumakhalabe kochepa, makamaka ponena za immunotherapy ya ma cell, yomwe imaphatikizapo kuchotsa maselo a chitetezo chamthupi kwa wodwala, kuwasintha kuti afufuze ndikuwononga khansa, ndiyeno kuwatembenuza kukhala wodwalayo.
"Tidapeza kuti kusintha kwa zotchinga zocheperako ngati ma nanometer 10 kumakhudza ntchito ya antitumor ya maselo athu oteteza thupi kapena ma cell opangidwa ndi immunotherapy," atero a Sangwu Park, wophunzira womaliza maphunziro awo ku labu ya Matthew Paszek ku Cornell University ku ISAB, New York. "Tagwiritsa ntchito chidziwitsochi kupanga maselo oteteza thupi omwe amatha kudutsa mu glycocalyx, ndipo tikukhulupirira kuti njirayi ingagwiritsidwe ntchito kukonza ma immunotherapy amakono." Biology.
"Labu yathu yabwera ndi njira yamphamvu yotchedwa scanning angle interference microscopy (SAIM) yoyeza ma nanosized glycocalyx a ma cell a khansa," adatero Park. "Njira yojambulirayi idatithandiza kumvetsetsa momwe ma mucins okhudzana ndi khansa amagwirira ntchito ndi biophysical properties za glycocalyx."
Ofufuzawo adapanga ma cellular model kuti azitha kuwongolera momwe ma cell mucins amawonekera kuti atsanzire glycocalyx yama cell a khansa. Kenako adaphatikiza SAIM ndi njira yama genetic kuti afufuze momwe kachulukidwe kake, glycosylation, ndi kulumikizana kwa ma mucin okhudzana ndi khansa kumakhudzira makulidwe a nanoscale chotchinga. Adasanthulanso momwe makulidwe a glycocalyx amakhudzira kukana kwa maselo kuti aukire ndi ma cell a chitetezo.
Kafukufukuyu akuwonetsa kuti makulidwe a cell cell glycocalyx ndi imodzi mwazinthu zazikulu zomwe zimatsimikizira kuti chitetezo chamthupi chimathamangitsidwa, komanso kuti maselo oteteza chitetezo chamthupi amagwira ntchito bwino ngati glycocalyx ndi yocheperako.
Malingana ndi chidziwitso ichi, ochita kafukufuku apanga maselo oteteza thupi omwe ali ndi ma enzyme apadera pamwamba pawo omwe amawalola kuti agwirizane ndi glycocalyx. Kuyesa pama cell akuwonetsa kuti maselo oteteza chitetezowa amatha kuthana ndi zida za glycocalyx zama cell a khansa.
Ofufuzawo amakonzekera kuti adziwe ngati zotsatirazi zikhoza kubwerezedwanso mu labu ndipo pamapeto pake m'mayesero azachipatala.
Sangwoo Park apereka phunziroli (chidule) pa gawo la "Regulatory Glycosylation in the Spotlight" Lamlungu, Marichi 26, 2-3 pm PT, Seattle Convention Center, room 608. Lumikizanani ndi gulu la atolankhani kuti mudziwe zambiri kapena kupita kwaulere ku msonkhano.
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Nthawi yotumiza: May-22-2023